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Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

Continuous downstream processing of biopharmaceuticals.

Alois Jungbauer¹

¹Department of Biotechnology, University of Natural Resources and Life Sciences Vienna--BOKU, Vienna, Austria. alois.jungbauer@boku.ac.at

Trends in Biotechnology

|July 16, 2013

Summary

Continuous manufacturing offers significant advantages for biopharmaceutical production, including improved productivity and robust purification of sensitive biomolecules. This approach is becoming increasingly viable due to advancements in chromatography and regulatory acceptance.

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Area of Science:

Biotechnology
Chemical Engineering
Pharmaceutical Manufacturing

Background:

Batch processing remains the standard in biotechnology, despite its limitations.
Continuous manufacturing offers potential benefits like increased productivity and reduced footprint.
Biotechnology has been slow to adopt continuous manufacturing compared to other industries.

Purpose of the Study:

To highlight the advantages of continuous manufacturing in biopharmaceutical production.
To discuss the available unit operations for continuous downstream processing.
To address the challenges and drivers for implementing continuous manufacturing in biotechnology.

Main Methods:

Review of existing unit operations for downstream processing.
Analysis of advancements in continuous chromatography.
Examination of regulatory and economic factors influencing adoption.

Main Results:

Continuous operation can enhance process productivity and reduce physical footprint.
Continuous chromatography is a mature technology enabling continuous downstream processing.
Regulatory challenges regarding 'batch' definition have been addressed.

Conclusions:

Continuous manufacturing is a viable and beneficial strategy for biopharmaceutical production.
Economic pressures and flexibility needs will drive the adoption of continuous manufacturing.
Parametric release considerations further support the shift towards continuous processing.