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[Clinical estimation of coronary risk factors with special reference to coronary arteriographic findings]
1First Department of Internal Medicine, Hiroshima University School of Medicine.
Insights
The Apo-B/Apo-AI ratio is a sensitive indicator of coronary artery stenosis severity in men. Aging, diabetes, hypertension, and this ratio significantly predict coronary artery disease progression.
Area of Science:
- Cardiology
- Atherosclerosis Research
- Lipid Metabolism
Background:
- Coronary artery stenosis (CS) severity is linked to various risk factors.
- Conventional atherogenic indices have limitations in predicting CS.
- Identifying sensitive markers for coronary heart disease is crucial.
Purpose of the Study:
- To investigate the relationship between coronary risk factors and the severity of coronary artery stenosis (CS) in male subjects.
- To evaluate the sensitivity of the apolipoprotein B/apolipoprotein AI (Apo-B/Apo-AI) ratio as a marker for CS compared to traditional indices.
- To identify key predictors of coronary artery arteriosclerosis severity.
Main Methods:
- Coronary arteriography was performed on 225 male subjects suspected of coronary heart disease.
- Coronary score (CS) was calculated to quantify stenosis severity.
- Statistical analyses, including regression, were used to assess correlations between CS and various risk factors, including the Apo-B/Apo-AI ratio.
Main Results:
- CS positively correlated with age, fasting blood sugar, uric acid, total cholesterol, LDL cholesterol, and apolipoprotein B.
- Alcohol consumption and apolipoprotein AI/AII levels were inversely correlated with CS.
- The Apo-B/Apo-AI ratio was the most sensitive index for CS, outperforming conventional atherogenic indices.
- Age, diabetes, hypertension, and the Apo-B/Apo-AI ratio accounted for approximately 27% of the variation in CS.
Conclusions:
- The Apo-B/Apo-AI ratio is a more sensitive marker for coronary artery stenosis severity than traditional atherogenic indices.
- Aging, diabetes mellitus, hypertension, and an elevated Apo-B/Apo-AI ratio are significant contributing factors to coronary arteriosclerosis severity in men.
Abstract:
The relationship between coronary risk factors and the severity of coronary artery stenosis (coronary score: CS) was estimated in 225 male subjects (aged 29-82 years, median 60 years old) who had undergone coronary arteriography for suspected coronary heart disease. CS was positively related to age, and levels of fasting blood sugar, uric acid, total cholesterol, low density lipoprotein cholesterol, and apolipoprotein B. Alcohol consumption, apolipoprotein AI and AII levels were inversely correlated to CS. Although, the level of CS was significantly higher in diabetics and hypertensives than in non-diabetics and non-hypertensives, the difference of CS level between diabetics and non-diabetics was more remarkable than that between hypertensives and non-hypertensives. Furthermore the ratio of Apo-B/Apo-AI was the most sensitive index of coronary artery stenosis rather than conventional atherogenic indices such as (TC-HDL-C)/HDL-C. Correlation between CS and the ratio of Apo-B/Apo-AI was positively and closely associated with aging, and this positive relationship was observed even in non-drinkers, heavier drinkers, non-diabetics and non-hypertensives. The reweighted least squares based on the least median of squares regression analysis indicated that about 27% of the variation in CS could be accounted for by age, complication of diabetes mellitus, complication of hypertension and the ratio of Apo-B/Apo-AI. These results indicate that the ratio of Apo-B/Apo-AI is a more sensitive parameter of the severity of coronary artery stenosis than any other atherogenic index. Further, aging, complication of diabetes mellitus, complication of hypertension and an increased level of the ratio of Apo-B/Apo-AI were responsible factors for the severity of coronary arteriosclerosis in male subjects.