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[Pediatric aids, 30 years later]

S Blanche1, C Dollfus, A Faye

  • 1Unité d'immunologie hématologie pédiatrique, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France. stephane.blanche@nck.aphp.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|July 16, 2013
PubMed

Insights

Perinatal HIV-1 transmission risk is nearly zero, with infected children now living stable, asymptomatic lives. Antiretroviral drugs have transformed pediatric AIDS into a manageable chronic condition.

Area of Science:

  • Pediatrics
  • Epidemiology
  • Infectious Diseases

Context:

  • Thirty years post-AIDS diagnosis in children, significant progress in prevention and treatment has been achieved.
  • The French perinatal epidemiological cohort, established in 1984, has tracked over 18,000 mother-child pairs.
  • Early 1980s saw the first descriptions of Acquired Immunodeficiency Syndrome (AIDS) in pediatric populations.

Purpose:

  • To outline the advancements in preventing and treating Human Immunodeficiency Virus type 1 (HIV-1) infection in children.
  • To highlight the long-term outcomes for children infected with HIV-1 during the perinatal period.
  • To document the impact of antiretroviral therapies on the progression of pediatric HIV-1 disease.

Summary:

  • Antiretroviral drugs have dramatically reduced mother-to-child HIV-1 transmission to near zero.
  • Children infected perinatally now experience a stable, asymptomatic, long-term condition, often achieving satisfactory life quality.
  • HIV-1 infection in children has transitioned from a rapidly progressing disease to a manageable chronic condition.

Impact:

  • Transformed pediatric HIV-1 care, enabling infected children to mature into adults with chronic, stable health.
  • Demonstrates the success of public health interventions and pharmaceutical advancements in managing infectious diseases.
  • Provides crucial epidemiological data on the long-term effects of HIV-1 in children and the effectiveness of treatment strategies.

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