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Updated: Oct 9, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Dominant vasodilator action of norepinephrine in isolated, non-preconstricted simian facial veins
1Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Abstract:
Using the cannula inserting method, we investigated the vascular responses to norepinephrine (NE), phenylephrine and isoprenaline (Isp) in isolated, perfused simian facial veins. NE usually induced only a vasodilation in non-preconstricted veins. Phenylephrine consistently induced only a slight vasoconstriction, and Isp produced only a vasodilation. NE-induced vasodilations were reversed to vasoconstrictions after treatment with a relatively larger dose of propranolol. It is concluded that simian facial veins have a spontaneous intrinsic tone and dominant abundant beta-adrenoceptors but sparse alpha 1-adrenoceptors.
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