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Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

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Updated: May 9, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Cannabis-associated arterial disease.

Anne Claire Desbois¹, Patrice Cacoub

¹Department of Internal Medicine, AP HP Goupe hospitalier Pitié-Salpêtrière, F-75013, Paris, France.

Annals of Vascular Surgery

|July 16, 2013

Summary

Cannabis use is linked to arterial issues like stroke and heart attack, particularly in young men. Quitting cannabis improves patient outcomes for these serious vascular conditions.

Area of Science:

Cardiovascular Medicine
Vascular Surgery
Toxicology

Background:

Arterial complications are increasingly reported in individuals who use cannabis.
Understanding these risks is crucial for patient care and public health.

Purpose of the Study:

To systematically review and describe arterial complications associated with cannabis smoking.
To identify patterns and characteristics of these vascular events.

Main Methods:

A comprehensive literature review was conducted.
Data from existing studies on cannabis use and arterial disease were analyzed.

Main Results:

Cannabis use is associated with stroke, myocardial infarction, and lower limb arteritis, predominantly in young men.

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A strong temporal relationship exists between cannabis use and arterial events, with increased risk within an hour of smoking.

Cannabis-associated arteritis presents uniquely in younger males, often affecting one lower limb.

Conclusions:

Cannabis use is a significant risk factor for serious arterial diseases, including stroke, myocardial infarction, and limb arteritis.
Investigating cannabis use is essential in young patients with arterial manifestations.
Patient outcomes are strongly influenced by cannabis cessation and relapse.