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An Open-Source Normothermic Perfusion System Designed for Research Scientists
Published on: July 18, 2025
Can we justify not doing liver perfusion imaging in 2013?
M Ronot1, S Lambert, J-L Daire
1Service de Radiologie, Hôpital Beaujon, 100, boulevard du Général-Leclerc, 92110 Clichy, France; Université Paris Diderot, Sorbonne Paris Cité, Inserm U773, Centre de Recherche Biomédicale Bichat-Beaujon, CRB3, Paris, France.
Diagnostic and Interventional Imaging
|July 16, 2013
Summary
Liver perfusion imaging assesses liver function but faces challenges from dual blood supply and imaging artifacts. Standardizing methods is crucial for wider clinical adoption in oncology and chronic liver disease.
Area of Science:
- Radiology
- Hepatology
- Medical Imaging
Background:
- Liver perfusion imaging is a complex quantitative functional assessment.
- Challenges include dual vascular supply, respiratory motion artifacts, and capillary diffusion.
- Ultrasound, CT, and MRI each have limitations and unique features for liver perfusion assessment.
Purpose of the Study:
- To review the applications and challenges of liver perfusion imaging.
- To highlight its role in hepatology, particularly in oncology and chronic liver disease.
- To emphasize the need for standardized acquisition and modeling.
Main Methods:
- Review of ultrasound, CT, and MRI techniques for liver perfusion imaging.
- Discussion of challenges in acquisition and data analysis.
- Exploration of clinical indications in hepatology.
Main Results:
- Liver perfusion imaging is complicated by anatomical and physiological factors.
- Current imaging modalities (ultrasound, CT, MRI) have limitations.
- Key applications include oncology and non-invasive assessment of chronic liver disease.
Conclusions:
- Standardization of acquisition and modeling methods is essential.
- Wider adoption of liver perfusion imaging requires addressing current limitations.
- Further development is needed to enhance the utility of this functional investigation.
