Related Experiment Video
Updated: May 9, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Newly diagnosed major depressive disorder and the risk of erectile dysfunction: a population-based cohort study in
Shiau-Shian Huang1, Ching-Heng Lin, Chin-Hong Chan
1Department of Psychiatry, Taichung Veterans General Hospital, Taiwan.
Introduction:
The primary aim of this study was to explore the incidence rate of erectile dysfunction (ED) among major depressive disorder (MDD) patients in an Asian country. The second aim was to compare the risk of ED in MDD patients that were treated using antidepressants with a high risk-ED, antidepressants with a low risk-ED, or without treatment.
Methods:
We identified 4339 male patients with newly diagnosed MDD using the National Health Database. Four matched controls per case were selected for the study.
Results:
The mean age of the participants was 42.3 ± 16.9. A higher crude HR of 3.6 (95% CI: 2.8-4.6) was seen in the male patients with MDD. After adjusting for obesity, monthly income, urbanization level, and comorbidity, the MDD patients had a 3.2-fold higher HR for an ED diagnosis than the controls. Patients with untreated depression had the highest risk of ED, compared to the control group (HR=3.9). Patients treated with IHiRA had a medium risk of developing ED (HR=3.6), and patients treated with ILoRA had the lowest risk of ED (HR: 2.5).
Conclusion:
This prospective cohort study found an association between ED and prior MDD. Patients with untreated depression may have the highest risk of developing ED.
Related Concept Videos
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Depression: Overview