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Related Experiment Video

Updated: May 9, 2026

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
09:39

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

Compact voltage and current stimulation buffer for high-density microelectrode arrays.

P Livi, F Heer, U Frey

    IEEE Transactions on Biomedical Circuits and Systems
    |July 16, 2013
    PubMed
    Summary
    This summary is machine-generated.

    We developed a compact microelectrode array buffer for precise voltage and current stimulation of electrogenic cells. This versatile circuit enables advanced neuronal culture research and applications.

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    Related Experiment Videos

    Last Updated: May 9, 2026

    Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
    09:39

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    Published on: June 7, 2016

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    Published on: October 18, 2013

    Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning
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    Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning

    Published on: October 22, 2015

    Area of Science:

    • Neuroscience
    • Electrical Engineering
    • Biomedical Engineering

    Background:

    • Electrogenic cell stimulation requires precise control over voltage and current.
    • Existing stimulation methods can be bulky or lack versatility.
    • Microelectrode arrays offer high-density cell interfacing.

    Purpose of the Study:

    • To develop a compact and versatile buffer for both voltage and current stimulation.
    • To integrate this buffer with a complementary metal-oxide semiconductor (CMOS) microelectrode array.
    • To evaluate the performance and applicability of the stimulation buffer.

    Main Methods:

    • Designed a compact buffer circuit (0.02 mm^2) utilizing a local common-mode feedback (LCMFB) amplifier.
    • Implemented voltage mode as a high-current class-AB voltage follower.
    • Implemented current mode as a type II current conveyor with cascode stages for increased gain.

    Main Results:

    • The buffer demonstrated good linearity across a 0.5-3.5 V input range.
    • The circuit successfully supported both voltage and current stimulation modes.
    • The buffer was extensively used for stimulating neuronal cultures.

    Conclusions:

    • The developed compact buffer provides a versatile solution for electrogenic cell stimulation.
    • This technology is suitable for advanced applications in neuronal culture research.
    • The integrated CMOS microelectrode array system enhances stimulation capabilities.