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Related Experiment Videos

Plasma exchange with a rotating filter.

A A Kaplan1, S E Halley

  • 1Department of Medicine, University of Connecticut School of Medicine, Farmington.

Kidney International
|July 1, 1990
PubMed
Summary
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A modified rotating filter system offers efficient therapeutic plasma exchange. This method accurately predicts treatment outcomes by estimating plasma volume, optimizing immunoglobulin removal for patients.

Area of Science:

  • Nephrology
  • Hematology
  • Biomedical Engineering

Background:

  • Therapeutic plasma exchange (TPE) is crucial for managing various medical conditions.
  • Optimizing TPE protocols requires efficient blood filtration and accurate prediction of plasma removal.
  • Existing methods may lack precision in predicting treatment efficacy, particularly for immunoglobulin removal.

Purpose of the Study:

  • To evaluate the efficacy and efficiency of a modified rotating filter system for therapeutic plasma exchange.
  • To assess the accuracy of predicting immunoglobulin removal based on estimated plasma volume (EPV).
  • To validate a simplified method for prescribing TPE based on immunoglobulin kinetics.

Main Methods:

  • A modified rotating filter system was utilized for TPE in 17 patients, totaling 188 treatments.

Related Experiment Videos

  • Blood flow rates, filtration fractions, and plasma removal rates were meticulously recorded.
  • Immunoglobulin (IgG, IgA, IgM) kinetics were analyzed, comparing apparent volume of distribution (AVD) with EPV.

    • Main Results:

    • The system achieved efficient plasma removal (mean 3231 ml/treatment) with a mean treatment time of 83 minutes.
    • Platelet count decline was minimal (15% decline).
    • High correlations were observed between expected and actual immunoglobulin decline (r=0.86 for IgG, r=0.88 for IgA, r=0.57 for IgM), validating the EPV method.

    Conclusions:

    • The modified rotating filter system provides a highly efficient and effective method for therapeutic plasma exchange.
    • The simplified EPV method allows for reliable prediction of TPE results, particularly for immunoglobulin levels.
    • This approach facilitates optimized and personalized TPE prescription.