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Design and Characteristics of a Multichannel Front-End ASIC Using Current-Mode CSA for Small-Animal PET Imaging.

N Ollivier-Henry, Wu Gao, Xiaochao Fang

    IEEE Transactions on Biomedical Circuits and Systems
    |July 16, 2013
    PubMed
    Summary

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    A new front-end readout integrated circuit (ASIC) was developed for multichannel-plate photodetectors. This design enhances spatial resolution and detection efficiency for positron emission tomography imaging systems.

    Area of Science:

    • Nuclear instrumentation
    • Integrated circuit design
    • Medical imaging technology

    Background:

    • Positron Emission Tomography (PET) systems require high-performance readout electronics for photodetectors.
    • Accurate energy and timing information is crucial for PET image quality.
    • Existing readout systems may face limitations in spatial resolution and detection efficiency.

    Purpose of the Study:

    • To design and characterize a novel front-end readout application-specific integrated circuit (ASIC).
    • To enable independent optimization of spatial resolution and detection efficiency in PET systems.
    • To provide a foundation for a high-sensitivity small-animal PET imaging system.

    Main Methods:

    • Design and fabrication of a 10-channel prototype ASIC using a 0.35-μm CMOS process.

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  • Utilized a current-mode charge-sensitive amplifier for signal processing.
  • Performed simulations and measurements to evaluate performance characteristics.

    • Main Results:

    • Achieved a gain of 13.1 mV/pC and a peak time of 280 ns.
    • Demonstrated a signal-to-noise ratio of 39 dB with an rms noise of 300 μV/√(Hz).
    • Exhibited nonlinearity <3% and crosstalk ~0.2%, with power dissipation <15 mW/channel.

    Conclusions:

    • The developed ASIC meets key performance metrics for PET imaging applications.
    • The prototype shows potential for integration into a 64-channel system with advanced converters.
    • This work paves the way for improved small-animal PET imaging systems.