Adenocarcinoma of the vermiform appendix

Area of Science:

• Gastroenterology
• Surgical Oncology
• Pathology

Background:

• Primary adenocarcinoma of the appendix is an exceptionally rare gastrointestinal neoplasm.
• This study reviews institutional experience with this rare malignancy over a 50-year period.

Purpose of the Study:

• To evaluate the presentation, clinical course, and outcomes of patients with primary appendiceal adenocarcinoma.
• To compare institutional findings with existing literature on this rare cancer.

Main Methods:

• Retrospective review of eleven patients diagnosed with primary adenocarcinoma of the appendix.
• Comparison of clinical data, treatment, and survival with published literature.

Main Results:

• Presenting signs, symptoms, and physical findings were consistent with literature reports.
• The 5-year survival rate was 20%, which is lower than reported in most series.
• Patients presented with advanced-stage disease at diagnosis.

Conclusions:

• Aggressive surgical therapy, specifically right hemicolectomy, is recommended for appendiceal adenocarcinoma.
• Despite challenges, aggressive treatment is crucial for achieving long-term survival in these rare cases.