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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
The prevalence of abnormal metabolic parameters in obese and overweight children
Deborah Salvatore1, Ava Satnick2, Rebecca Abell2
1Stony Brook Long Island Children's Hospital, Stony Brook, New York deborah.salvatore@stonybrookmedicine.edu.
Insights
Obese children, particularly those in classes II and III, frequently exhibit abnormal metabolic markers like low HDL cholesterol and elevated insulin. Obesity severity correlates with these laboratory abnormalities, indicating increased health risks.
Area of Science:
- Pediatric Endocrinology
- Metabolic Disorders
- Obesity Research
Background:
- Obesity in children is a growing concern with potential metabolic complications.
- Understanding the link between obesity severity and metabolic dysfunction is crucial for early intervention.
Purpose of the Study:
- To determine the prevalence of abnormal metabolic parameters in obese children.
- To investigate the correlation between the degree of obesity (classified by BMI) and metabolic abnormalities.
Main Methods:
- Retrospective analysis of 101 obese children from a pediatric obesity clinic.
- Obesity classified into classes I, II, and III based on BMI percentiles.
- Evaluation of metabolic parameters including HDL cholesterol, fasting insulin, and ALT levels.
- Statistical analysis using chi-squared tests and ANOVA.
Main Results:
- 80% of obese children had low HDL cholesterol; 58% had elevated fasting insulin; 32% had elevated ALT.
- Class II obesity was associated with double the ALT levels compared to Class I (P=.036).
- Fasting insulin, ALT, HDL cholesterol, and triglycerides showed trends correlating with obesity class.
Conclusions:
- Children with Class II and III obesity face a higher risk of abnormal laboratory findings.
- Classifying obesity severity is vital for predicting comorbidities and guiding clinical management.
- Obesity classes can serve as a screening tool for risk assessment in pediatric populations.
Background:
This retrospective study aimed to determine the prevalence of abnormal metabolic parameters in obese children and its correlation to the degree of obesity determined by body mass index (BMI).
Methods:
In total, 101 children seen at the Pediatric Gastroenterology Obesity Clinic at Stony Brook Children's University Hospital were enrolled in the study. The degree of obesity was characterized according to the following formula: (patient's BMI/BMI at 95th percentile) × 100%, with class I obesity >100%-120%, class II obesity >120%-140%, and class III obesity >140%. A set of metabolic parameters was evaluated in these patients. Frequency distributions of all study variables were examined using the χ(2) test of independence. Mean differences among the obesity classes and continuous measures were examined using 1-way analysis of variance.
Results:
Within our study population, we found that 80% of our obese children had a low high-density lipoprotein (HDL) cholesterol level, 58% had elevated fasting insulin levels, and 32% had an elevated alanine aminotransferase (ALT) level. Class II obese children had a 2-fold higher ALT value when compared with class I children (P = .036). Fasting insulin, ALT, HDL cholesterol, and triglyceride levels trended with class of obesity.
Conclusion:
Obese children in classes II and III are at higher risk for developing abnormal laboratory values. We recommend obese children be further classified to reflect the severity of the obesity since this has predictive significance for comorbidities. Obesity classes I, II, and III could help serve as a screening tool to help communicate risk assessment.
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