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ATM signalling and cancer

C A Cremona1, A Behrens1

  • 1Mammalian Genetics Lab, Cancer Research UK London Research Institute, London, UK.

Oncogene
|July 16, 2013
PubMed

Insights

Ataxia telangiectasia (A-T) protein kinase (ATM) mutations are linked to cancer predisposition and tumor development. Research explores ATM signaling in DNA damage, redox biology, and its therapeutic inhibition for cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • ATM kinase is central to DNA damage response and redox signaling.
  • Mutations in ATM cause ataxia telangiectasia (A-T), a rare human disease.
  • ATM alterations are implicated in both germline cancer predisposition and somatic tumor mutations.

Purpose of the Study:

  • To review ATM's role in DNA damage response and cancer.
  • To summarize ATM alterations in germline and somatic cancer.
  • To discuss ATM signaling mechanisms and inhibition strategies in cancer therapy.

Main Methods:

  • Literature review of ATM research over two decades.
  • Analysis of genomic data revealing ATM alterations.
  • Synthesis of findings on ATM signaling pathways.

Main Results:

  • ATM is crucial for cellular response to DNA damage.
  • ATM alterations are identified as cancer predisposing factors and somatic mutations in tumors.
  • ATM signaling provides insights into cancer mechanisms.

Conclusions:

  • ATM plays a significant role in cancer development and progression.
  • Understanding ATM signaling is key for developing targeted cancer therapies.
  • ATM inhibition represents a promising strategy for cancer treatment.

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