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Updated: May 9, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Acute treatment of anaphylaxis in children
1BC Children's Hospital, Department of Pediatrics, Room K4-226, Ambulatory Care Bldg, 4480 Oak St, Vancouver, BC V6H 3V4. rgoldman@cw.bc.ca
Insights
The best treatment for childhood anaphylaxis is intramuscular epinephrine injection. Children with severe allergies should always carry an epinephrine autoinjector and be educated on its proper use.
Area of Science:
- Pediatric Allergy and Immunology
- Emergency Medicine
Background:
- Anaphylaxis is a severe, life-threatening allergic reaction.
- Prompt recognition and treatment are crucial for positive outcomes in children.
Purpose of the Study:
- To determine the optimal treatment for pediatric anaphylaxis.
- To assess the necessity and proper use of epinephrine autoinjectors in children experiencing allergic reactions.
Main Methods:
- Case presentation of a 3-year-old child experiencing anaphylaxis after nut ingestion.
- Review of current treatment guidelines for anaphylaxis in pediatric patients.
Main Results:
- Intramuscular epinephrine injection is confirmed as a safe and effective first-line treatment for pediatric anaphylaxis.
- Epinephrine autoinjectors are recommended for immediate use during systemic allergic reactions.
Conclusions:
- Children with a history of anaphylaxis must carry epinephrine autoinjectors consistently, including at school.
- Education on the correct usage and expiration dates of epinephrine autoinjectors is vital for families and children.
Question:
A 3-year-old was rushed to my office after eating a friend's chocolate bar that contained nuts. He immediately developed urticaria on his face and swelling of his lips, and he had a persistent cough. What is the best treatment for a child with anaphylaxis? Should this family receive a prescription for an epinephrine autoinjector device?
Answer:
Intramuscular epinephrine injection is a safe and effective treatment of anaphylaxis in children. Children with systemic allergic reactions should carry epinephrine autoinjectors at all times, and should certainly have one with them at school. In order for epinephrine autoinjectors to be effective, children and their families need to be educated on how to properly use the devices, as well as keep in mind the product's expiration date.
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