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Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...

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Micromanaging abdominal aortic aneurysms.

Lars Maegdefessel1, Joshua M Spin, Matti Adam

  • 1Department of Medicine, Karolinska Institute, Stockholm SE-17176, Sweden. lars.maegdefessel@ki.se

International Journal of Molecular Sciences
|July 16, 2013
PubMed
Summary
This summary is machine-generated.

MicroRNAs regulate gene expression and are key in abdominal aortic aneurysm (AAA) development. Modulating microRNA levels offers promising therapeutic strategies for limiting AAA expansion and rupture.

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Area of Science:

  • Vascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Abdominal aortic aneurysm (AAA) poses a growing health burden due to increased morbidity and mortality in aging populations.
  • Understanding the molecular and pathophysiological mechanisms of AAA is crucial for developing effective treatments.
  • Complex gene regulation, including microRNAs, is essential for maintaining aortic vascular homeostasis.

Purpose of the Study:

  • To explore the role of microRNAs in the initiation and progression of abdominal aortic aneurysms.
  • To review current findings on microRNA expression modulation as a therapeutic strategy for AAA.
  • To assess the clinical and translational feasibility of future microRNA-based therapies for AAA.

Main Methods:

  • Review of existing literature on microRNA involvement in AAA.
  • Analysis of studies using disease-relevant murine models of AAA.
  • Examination of human tissue samples from patients undergoing surgical repair of aortic aneurysms.

Main Results:

  • MicroRNAs (miRNAs) are identified as critical regulators of gene expression at transcriptional and post-transcriptional levels.
  • miRNAs fine-tune messenger RNA (mRNA) output by promoting degradation or inhibiting translation.
  • Evidence suggests microRNA expression modulation plays significant roles in AAA initiation and propagation.

Conclusions:

  • MicroRNAs are powerful regulators with potential as therapeutic targets for various diseases, including AAA.
  • Modulating microRNA expression presents a promising avenue for limiting AAA expansion and preventing rupture.
  • Future research should focus on the clinical and translational application of microRNA-based therapies for AAA management.