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Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Deformation field validation and inversion applied to adaptive radiation therapy.

Tom Vercauteren¹, Werner De Gersem, Luiza A M Olteanu

¹Department of Radiotherapy, Ghent University Hospital, Belgium. tom.vercauteren@uzgent.be

Physics in Medicine and Biology

|July 16, 2013

Summary

This study introduces new methods for dose accumulation in adaptive radiation therapy for head and neck cancer, improving accuracy by detecting and correcting dose calculation errors.

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Area of Science:

Radiation Oncology
Medical Physics
Image Processing

Background:

Adaptive intensity-modulated radiation therapy (IMRT) requires accurate dose accumulation.
Deformable image registration (DIR) is crucial for dose accumulation in IMRT.
Challenges exist in propagating dose accurately through deformable image data.

Purpose of the Study:

To develop and implement chronological and anti-chronological adaptive dose accumulation strategies.
To create algorithms for efficient computation of inverse deformation fields (DFs).
To ensure valid dose propagation through robust verification steps.

Main Methods:

Implemented an algorithm using Newton iterations for inverse DF computation.
Developed four verification steps: intra-cell folding, inter-cell folding, undefined value detection, and DF domain display.
Utilized Atlas-based autosegmentation (ABAS) for contour propagation and DF generation.
Performed deformable image registration-based dose accumulations on CT data.

Main Results:

Successfully implemented chronological and anti-chronological dose accumulation algorithms based on DF inversion.
Demonstrated the algorithms' capability to detect and handle cell folding during dose propagation.
Illustrated the dose accumulation process using a patient case with multiple (18)F-FDG-PET/CT scans.

Conclusions:

The developed algorithms enable accurate dose accumulation in adaptive IMRT for head and neck cancer.
The implemented verification steps enhance the reliability of dose propagation.
This work contributes to improved treatment planning and delivery in adaptive radiation therapy.