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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 9, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Multiple internal resorption in permanent teeth associated with hyperparathyroidism.

Eswar Nagaraj1, Roopam Pal Kaur, P H Raghuram

  • 1Department of Oral Medicine and Radiology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, India.

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
|July 16, 2013
PubMed
Summary
This summary is machine-generated.

This study highlights a rare case of multiple internal tooth resorptions linked to elevated parathyroid hormone (PTH) and uric acid levels. This finding suggests a potential systemic connection to internal root resorption.

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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Last Updated: May 9, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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Published on: August 17, 2022

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

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Area of Science:

  • Dentistry
  • Endodontics
  • Oral Pathology

Background:

  • Internal resorption is a dental defect where pulp tissue transforms, leading to dentin resorption.
  • While often idiopathic, factors like trauma and caries can contribute; typically affecting single teeth.
  • External root resorption is commonly linked to systemic conditions like renal disease and hyperparathyroidism.

Observation:

  • A 28-year-old female presented with fractured permanent teeth and multiple internal resorptions.
  • Resorptions affected incisors, canines, and premolars, sparing molars.
  • Elevated parathyroid hormone (PTH) and uric acid levels were noted.

Findings:

  • This case presents a rare association between multiple internal root resorptions and hyperparathyroidism.
  • The patient's elevated PTH and uric acid levels suggest a potential systemic etiology for the widespread internal resorption.
  • This contrasts with the more common association of external root resorption with systemic disorders.

Implications:

  • This case suggests hyperparathyroidism may be a contributing factor to multiple internal root resorptions.
  • Further research is needed to explore the link between systemic metabolic disorders and internal resorption.
  • Understanding these associations can improve diagnosis and management of complex dental cases.