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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Muscles of the Eye01:20

Muscles of the Eye

The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and rotating...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Updated: May 9, 2026

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
06:54

Dissection of Human Retina and RPE-Choroid for Proteomic Analysis

Published on: November 12, 2017

The human eye proteome project.

Gilbert S Omenn1

  • 1Center for Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2218, USA. gomenn@umich.edu

Proteomics
|July 16, 2013
PubMed
Summary
This summary is machine-generated.

The Human Eye Proteome Project establishes a baseline for eye proteins. Future research will generate new data following strict Human Proteome Project guidelines.

Keywords:
Biology and Disease-driven Human Proteome ProjectBiomedicineEye proteomeHuman Proteome Project

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Last Updated: May 9, 2026

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Published on: November 12, 2017

Sample Preparation for Mass-spectrometry-based Proteomics Analysis of Ocular Microvessels
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Published on: January 23, 2011

Area of Science:

  • Ophthalmology
  • Proteomics
  • Human Biology

Background:

  • The Human Eye Proteome Project (HPP) is a new initiative.
  • Understanding the eye's protein composition is crucial for diagnosing and treating eye diseases.
  • Previous research has not comprehensively cataloged the eye's proteome across all its anatomical compartments.

Purpose of the Study:

  • To establish a provisional baseline for the human eye proteome.
  • To provide a foundation for future research within the Biology and Disease-driven HPP.
  • To define stringent guidelines for protein identification and characterization in the context of the eye.

Main Methods:

  • Literature review to compile existing proteomic data for the eye.
  • Utilizing the established Human Proteome Project (HPP) guidelines for protein identification.
  • Planning for the generation of new experimental data on the human eye proteome.

Main Results:

  • A provisional baseline of the human eye proteome has been established.
  • The proteomes of various anatomical compartments of the eye are provisionally defined.
  • The study highlights the need for further data generation adhering to HPP standards.

Conclusions:

  • The human eye proteome is a complex and emerging area of research.
  • The established baseline serves as a critical starting point for the Human Eye Proteome Project.
  • Future work will expand our understanding of the eye proteome, aiding in disease research.