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First and second trimester biochemical markers in familial mediterranean fever
F Turkcapar1, Y Engin-Üstün, O Y Simsek
1Gynecology and Obstetrics Department, Zekai Tahir Burak Woman's Health Education and Research Hospital, Ankara, Turkey. fcapar@yahoo.com
Objectives:
Our aim was to investigate whether the maternal serum concentrations of first and second trimester serum analytes are altered in familial Mediterranean fever (FMF) pregnancies.
Materials And Methods:
The screening tests were compared in a series of 16 serum samples from FMF pregnancies and in a cohort of 48 pregnant women with normal pregnancy. Serum samples were obtained between 11 and 13 weeks; 16 and 18 weeks gestation.
Results:
Serum pregnancy-associated plasma protein-A (PAPP-A) levels, expressed as multiples of the median (0.9 ± 0.45 MoM) in the control group, were significantly higher than FMF patients (0.6 ± 0.3 MoM) (p = 0.027). Analyses of alpha-fetoprotein, human chorionic gonadotropin and oestriol levels showed no significant differences between FMF and normal pregnancies.
Conclusions:
Our study revealed that low levels of PAPP-A are associated with FMF.
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