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Related Experiment Video

Updated: May 9, 2026

Measurement of Bioelectric Current with a Vibrating Probe

Measurement of Bioelectric Current with a Vibrating Probe

Published on: January 4, 2011

CMOS low current measurement system for biomedical applications.

Brian Goldstein¹, Dongsoo Kim, Jian Xu

¹Department of Electrical Engineering, Yale University, New Haven, CT 06520, USA. brian.goldstein@yale.edu

IEEE Transactions on Biomedical Circuits and Systems

|July 16, 2013

Summary

This summary is machine-generated.

This study introduces a low-noise micro-chip for measuring tiny electrical currents in biomedical research. The system achieves 190 fA RMS noise, crucial for applications like DNA sequencing and cell studies.

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Area of Science:

Biomedical Engineering
Electronics
Biophysics

Background:

Accurate measurement of low currents is essential for various biomedical applications, including DNA sequencing and patch-clamp electrophysiology.
Existing systems often face challenges with noise and power consumption, limiting their applicability.

Purpose of the Study:

To develop and demonstrate a micro-chip implementation of a low-current measurement system for biomedical applications.
To achieve high sensitivity and low noise performance for precise signal detection.

Main Methods:

A micro-chip system utilizing capacitive feedback for low current measurement.
Implementation using a 0.5-μm 3-metal 2-poly CMOS process, with two channels on a 630 × 440 μm² area.
Characterization using a 10 GΩ resistor and 47 pF capacitor, simulating cell membrane properties.

Main Results:

Achieved 190 fA of RMS noise in a 1 kHz bandwidth.
Demonstrated a measured RMS noise of 2.44 pA on a 50 pA signal in a 10 kHz bandwidth under simulated biological conditions.
Selectable sampling rate up to 100 kHz.
Each channel consumes 1.5 mW of power from a 3.3 V supply.

Conclusions:

The developed micro-chip system offers a highly sensitive and low-noise solution for biomedical current measurements.
Its compact size, low power consumption, and high performance make it suitable for advanced applications like DNA sequencing and patch-clamp studies.
The system's characteristics were validated through measurements on an artificial lipid bilayer, relevant to nanopore-based DNA sequencing.