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Changing profile of rotavirus genotypes in Bangladesh, 2006-2012

Mokibul Hassan Afrad1, Zahid Hassan, Saiada Farjana

  • 1Virology Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, Bangladesh.

BMC Infectious Diseases
|July 17, 2013
PubMed

Insights

Rotavirus prevalence in Bangladesh is significant, with common genotypes like G1P[8] and G9P[8]. Understanding these rotavirus strains is crucial for effective vaccine strategies in the region.

Area of Science:

  • Medical Microbiology
  • Vaccinology
  • Public Health

Background:

  • Rotavirus is a primary cause of severe infant diarrhea globally, including Bangladesh.
  • Licensed rotavirus vaccines exhibit reduced efficacy in Bangladeshi trials compared to high-income nations.

Purpose of the Study:

  • To determine rotavirus prevalence and genotype distribution in Bangladesh over a six-year period.
  • To establish baseline data on rotavirus burden and its evolving profile in the country.

Main Methods:

  • Stool samples from diarrhea patients in Matlab, Bangladesh (June 2006-May 2012) were analyzed.
  • Group A rotaviruses were detected using ELISA and genotyped via multiplex RT-PCR and sequencing.

Main Results:

  • Rotavirus was detected in 20.3% of 9678 stool samples.
  • Predominant genotypes included G1P[8] (22.4%), G9P[8] (20.8%), G2P[4] (16.9%), and G12P[8] (10.4%).
  • An unusual G9P[4] strain emerged, and antigenic mismatches were noted between local and vaccine strains.

Conclusions:

  • The identified rotavirus genotypes in Bangladesh necessitate careful consideration for rotavirus vaccine selection and implementation.
  • This data is vital for optimizing vaccine effectiveness and public health strategies against rotavirus disease in the region.
Abstract

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