Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 9, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

PEG-stabilized core-shell surface-imprinted nanoparticles.

Ewa Moczko1, Antonio Guerreiro, Elena Piletska

  • 1Cranfield Health, Cranfield University, Cranfield, Bedfordshire MK43 0AL, UK. ewa.moczko@cranfield.ac.uk

Langmuir : the ACS Journal of Surfaces and Colloids
|July 17, 2013
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecularly imprinted plasmonic nanosensors: A reagent-free platform for ultrasensitive, real-time drug detection in complex biofluids.

Talanta·2026
Same author

Molecularly Imprinted Polymer Nanoparticles for Lung-Cancer-Cell-Surface Proteomics.

Polymers·2026
Same author

Development of one-step magnetic assay for the detection of fentanyl.

The Analyst·2025
Same author

Molecularly imprinted polymer-integrated nanozymes for biosensing: advances and prospects.

Journal of materials chemistry. B·2025
Same author

Adsorption Isotherm Analysis for Hybrid Molecularly Imprinted Polymeric Gold-Decorated Nanoparticles Suitable for Reliable Quantification of Gluconic Acid in Wine.

Nanomaterials (Basel, Switzerland)·2025
Same author

Validation of a smartphone-compatible MIP-based sensor for bisphenol A determination in wastewater samples.

Analytical and bioanalytical chemistry·2024
Same journal

Immobilization of Ytterbium via Polyphenol Chemistry on Implant Materials for Enhanced Cytocompatibility and Antibacterial Properties.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Electrochemical Oxidation Strategy for Integrated CO<sub>2</sub> Capture and Conversion.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Probing Molecular Structural Changes of Buried Interfaces between Polyethylene and Nylon in Polymer Thin Films after Stretching.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Charge Dependence of Local Hydration Dynamics in Poly(Acrylic Acid) Solutions.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Amphiphilic Lubricants Linked by Hydrogen Bonds Achieve Superlubricity and Enhance Water/Oil Tribological Properties.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Spin Dewetting of Ultrathin Polymer Films.

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

We developed a method to create stable molecularly imprinted polymeric nanoparticles (MIP NPs). Surface modification with poly(ethylene glycol) prevents aggregation, enhancing stability for applications like drug delivery.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Nanomaterials, including molecularly imprinted polymeric nanoparticles (MIP NPs), often suffer from aggregation in suspensions, limiting their practical applications.
  • Surface modification is crucial for improving the stability and dispersibility of nanoparticles in various biological and chemical environments.

Purpose of the Study:

  • To develop a technique for producing target-specific MIP NPs with enhanced colloidal stability.
  • To investigate the effect of poly(ethylene glycol) (PEG) surface modification on MIP NP stability in aqueous solutions and biological media.
  • To ensure that surface modification does not compromise the molecular recognition capabilities of the MIP NPs.

Main Methods:

  • Synthesis of target-specific MIP NPs using a solid-phase approach.

More Related Videos

Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
06:24

Preparation of Nanoparticles for ToF-SIMS and XPS Analysis

Published on: September 13, 2020

Generation of Zerovalent Metal Core Nanoparticles Using n-(2-aminoethyl)-3-aminosilanetriol
08:12

Generation of Zerovalent Metal Core Nanoparticles Using n-(2-aminoethyl)-3-aminosilanetriol

Published on: February 11, 2016

Related Experiment Videos

Last Updated: May 9, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
06:24

Preparation of Nanoparticles for ToF-SIMS and XPS Analysis

Published on: September 13, 2020

Generation of Zerovalent Metal Core Nanoparticles Using n-(2-aminoethyl)-3-aminosilanetriol
08:12

Generation of Zerovalent Metal Core Nanoparticles Using n-(2-aminoethyl)-3-aminosilanetriol

Published on: February 11, 2016

  • Surface modification of MIP NPs by grafting polymerizable poly(ethylene glycol).
  • Evaluation of nanoparticle stability in water, phosphate buffer, and in the presence of serum proteins.

    • Main Results:

    • Surface modification with PEG significantly improved the dispersibility, storage, and colloidal stability of MIP NPs.
    • Grafted polymer shell reduced surface energy and enhanced polarity, leading to better stability compared to unmodified NPs.
    • The solid-phase synthesis approach protected the binding sites, preserving the recognition properties of the MIP NPs.

    Conclusions:

    • Surface-modified MIP NPs exhibit superior stability and dispersibility, overcoming aggregation issues.
    • The developed method allows for the creation of nanomaterials with selective molecular recognition and improved biocompatibility.
    • These stable MIP NPs hold potential for advanced applications in drug delivery, imaging, and other in vivo technologies.