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Biosynthetic origins of menisporopsin A
Pakorn Wattana-amorn1, Punika Juthaphan, Maturin Sirikamonsil
1Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Ladyaow, Chatuchak, Bangkok 10900, Thailand.
Abstract:
Menisporopsin A, produced by Menisporopsis theobromae, shows antimalarial, antimycobacterial, and cytotoxic activities. Here, we report the first (13)C incorporations at individual carbons of menisporopsin A using sodium [1-(13)C] and [2-(13)C] acetate. This result indicates that each of the subunits of the pentalactone menisporopsin A is assembled by a polyketide synthase.
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