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Updated: May 9, 2026
12:13
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
Long noncoding RNAs: new players in prostate cancer
Wen Cheng1, Zhengyu Zhang, Jiangdong Wang
1Department of Urology, Jinling Hospital, Nanjing, Jiangsu 210002, China.
Cancer Letters
|July 17, 2013
Summary
Long noncoding RNAs (lncRNAs) are crucial in prostate cancer development. This review explores their roles, highlighting potential for diagnosis, prognosis, and treatment of this common male cancer.
Area of Science:
- Molecular Oncology
- Genomics
- Cancer Biology
Background:
- Prostate cancer is a leading cause of male cancer mortality globally.
- The molecular mechanisms driving prostate cancer remain incompletely understood.
- Long noncoding RNAs (lncRNAs) are increasingly recognized as key players in cancer development.
Purpose of the Study:
- To review recent findings on the roles of lncRNAs in prostate cancer.
- To discuss the translational potential of lncRNA research for clinical applications.
Main Methods:
- Literature review of recent studies on lncRNAs in prostate cancer.
- Analysis of lncRNA expression patterns and functional roles (oncogenic and tumor-suppressive).
Main Results:
- Hundreds of lncRNAs are differentially expressed in prostate cancer.
- Some lncRNAs function as oncogenes (Onco-lncRNAs), promoting cancer progression.
- Other lncRNAs act as tumor suppressors by inhibiting cell proliferation and inducing apoptosis.
Conclusions:
- lncRNAs play diverse and significant roles in prostate cancer.
- Further research into lncRNAs offers promising avenues for improved diagnosis, prognosis, and therapeutic strategies.
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