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Protein Glycosylation

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...

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Dot by dot: analyzing the glycome using lectin microarrays.

João P Ribeiro¹, Lara K Mahal

¹Biomedical Chemistry Institute, New York University, 100 Washington Square East, Room 1001, New York, NY 10003, USA.

Current Opinion in Chemical Biology

|July 17, 2013

Summary

This summary is machine-generated.

Lectin microarrays offer a powerful method for analyzing the complex carbohydrates (glycans) in cells and tissues. This technology provides a global view of the glycome, aiding in health and disease research.

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Area of Science:

Glycomics
Carbohydrate chemistry
Biotechnology

Background:

The glycome, encompassing all carbohydrates in a cell or tissue, is crucial for biological interactions in health and disease.
Glycans are structurally complex and challenging to analyze.
Lectin microarrays offer a sensitive, high-throughput approach for glycomic profiling.

Purpose of the Study:

This review focuses on recent advancements in lectin microarray technology.
To highlight the utility of lectin microarrays in various biological studies.

Main Methods:

Lectin microarrays enable global glycome analysis.
High-throughput and sensitive detection of glycan structures.

Main Results:

Lectin microarray technology has been successfully applied in diverse studies.
Applications include identifying glycan-based stem cell markers.
Detection of pathogens and early disease diagnosis are also facilitated.

Conclusions:

Lectin microarrays are a valuable tool for comprehensive glycomic profiling.
Advances in this technology continue to expand its applications in biological research and diagnostics.