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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Copeptin during rest and exercise in major depression.

Jesper Krogh¹, Jens Peter Gøtze, Martin Balslev Jørgensen

¹Mental Health Centre Copenhagen, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Jesper.krogh@regionh.dk

Journal of Affective Disorders

|July 17, 2013

Summary

Copeptin levels are not elevated in depression and show no association with cortisol or ACTH. Aerobic exercise training only decreased copeptin in highly compliant patients, suggesting vasopressin may not play a significant role in depression.

Keywords:

ACTH Copeptin Depression Exercise test Exercise training Vasopressin

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Area of Science:

Neuroendocrinology
Psychiatry
Exercise Physiology

Background:

Elevated vasopressin and its correlation with cortisol are observed in depression.
Copeptin, a marker of vasopressin, was investigated for its association with cortisol and ACTH in depression.
The study also explored the impact of exercise on copeptin levels.

Purpose of the Study:

To assess copeptin levels and their association with cortisol and ACTH in patients with depression.
To examine the response of copeptin to acute exercise and aerobic training interventions.

Main Methods:

Copeptin, ACTH, and cortisol were measured in 111 depressed patients and 57 controls.
Copeptin was measured at rest and during exercise.
Depressed patients underwent randomization to aerobic training or an exercise control group.

Main Results:

Plasma copeptin levels did not differ significantly between depressed subjects and controls.
No significant association was found between copeptin and cortisol or ACTH, independent of depression status.
Aerobic exercise training did not influence resting copeptin levels or the acute exercise response, except for a decrease in high-compliance participants.

Conclusions:

Copeptin levels are not elevated and are not associated with ACTH or cortisol in depressed patients.
Aerobic exercise training led to decreased copeptin levels only in participants with high adherence.
The findings do not support a significant role for copeptin or vasopressin in the pathophysiology of depression.