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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
Carbon nanotubes in neuroregeneration and repair
Alessandra Fabbro1, Maurizio Prato, Laura Ballerini
1Life Science Department, University of Trieste, via Giorgieri 1, I-34127 Trieste, Italy.
Advanced Drug Delivery Reviews
|July 17, 2013
Summary
Carbon nanotubes show promise for repairing the nervous system. These nanomaterials can interface with neurons, aiding in nerve tissue engineering for functional recovery after brain damage.
Area of Science:
- Neuroscience
- Biomaterials Science
- Nanotechnology
Background:
- Growing interest in nanotechnology for nervous system applications.
- Developing strategies for functional recovery after brain damage is crucial.
- Carbon nanotubes possess unique physical properties and neuronal interfacing capabilities.
Purpose of the Study:
- To review the current state of carbon nanotube technology in nerve tissue repair.
- To highlight advancements in using carbon nanotubes for neural engineering.
- To focus on carbon nanotubes' impact on neuronal differentiation, growth, and network reconstruction.
Main Methods:
- Literature review of carbon nanotube applications in neuroscience.
- Analysis of studies on carbon nanotubes for nerve tissue engineering.
- Synthesis of findings on neuronal differentiation, growth, and network repair.
Main Results:
- Carbon nanotubes are effective in interfacing with neuronal circuits, synapses, and membranes.
- These nanomaterials show potential in promoting neuronal differentiation and growth.
- Carbon nanotubes contribute to nerve network reconstruction for tissue repair.
Conclusions:
- Carbon nanotube technology is a key innovation for nerve tissue repair.
- These nanomaterials offer promising strategies for functional recovery after brain damage.
- Further research in carbon nanotube-based nerve tissue engineering is warranted.
Keywords:
AdhesionAxonsCNSDRGECMENERKFAKKCC2LBLMAP2MEAMSCMWCNTNCAMNGFNSCNanomaterialNanotopographyNetwork activityNeurite growthNeuronal membranePAAPABSPEGPEIPLCLPLOSEMSMI-32SWCNTScaffoldStem cell differentiationSynaptic activityantibody recognizing non-phosphorylated neurofilamentscentral nervous systemdorsal root gangliaethylenediamineextracellular matrixextracellular signal-regulated kinasefew-walled CNTfocal adhesion kinasefwCNTlayer-by-layermesenchymal stem cellsmicrotubule-associated protein 2multi-electrode arraymulti-walled carbon nanotubesnerve growth factorneural cell adhesion moleculeneural stem cellspoly(acrylic acid)poly(l-lactic acid-co-caprolactone)poly-m-aminobenzene sulfonic acidpolyethylene glycolpolyethyleneiminepolyornithinepotassium chloride cotransporter 2scanning electron microscopesiRNAsingle-walled carbon nanotubessmall interfering RNA
