Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the appropriate...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Interplay of Dispersion and Thermal Shock in Pseudomonas Aeruginosa Biofilms.

Biotechnology and bioengineering·2026
Same author

Dispersion Inhibits Thermal Mitigation of Pseudomonas aeruginosa Biofilms on Self-Heating Surfaces.

MicrobiologyOpen·2026
Same author

Antibiotic Augmentation of Thermal Eradication of <i>Staphylococcus epidermidis</i> Biofilm Infections.

Pathogens (Basel, Switzerland)·2024
Same author

Thermal susceptibility and antibiotic synergism of methicillin-resistant <i>Staphylococcus aureus</i> biofilms.

Biofouling·2023
Same author

Thermal Shock and Ciprofloxacin Act Orthogonally on <i>Pseudomonas aeruginosa</i> Biofilms.

Antibiotics (Basel, Switzerland)·2021
Same author

Magnetic nanoparticle/polymer composites for medical implant infection control.

Journal of materials chemistry. B·2020

Related Experiment Video

Updated: May 9, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

BioMEMS in drug delivery.

Eric Nuxoll1

  • 1Department of Chemical and Biochemical Engineering, Seamans Center for the Engineering Arts & Sciences, University of Iowa, Iowa City, IA 52245, USA.

Advanced Drug Delivery Reviews
|July 17, 2013
PubMed
Summary

Biologically-oriented microelectromechanical systems (BioMEMS) enable precise microneedle drug delivery and implantable pumps. These micro-scale devices offer advancements in drug formulation and personalized medicine.

Keywords:
BioMEMSControlled releaseDrug deliveryMicrofabricationMicroneedleMicroparticlesMicropumpsMicrovalvesNanoparticlesPhotolithography

Related Experiment Videos

Last Updated: May 9, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • The demand for mass-producible micro-scale medical devices has led to the adoption of semiconductor processing technologies.
  • Biologically-oriented microelectromechanical systems (BioMEMS) leverage micro-scale engineering for medical applications.
  • Current drug delivery methods face limitations addressable by micro-scale technologies.

Purpose of the Study:

  • To review the current state of BioMEMS technologies for drug delivery.
  • To highlight the opportunities presented by BioMEMS in improving drug delivery systems.
  • To discuss the integration of BioMEMS with other microelectromechanical systems (MEMS).

Main Methods:

  • Review of existing literature on BioMEMS applications in drug delivery.
  • Analysis of semiconductor industry processing techniques adapted for BioMEMS.
  • Discussion of micromolding and microfluidic devices for particle formation.

Main Results:

  • BioMEMS enable precise microneedle-based drug delivery, including low-dose vaccinations and painless transdermal administration.
  • Implantable low-power, low-volume BioMEMS pumps and reservoirs offer new possibilities for localized drug delivery.
  • Micromolding and microfluidics facilitate the formation of uniform micro- and nanoparticles for advanced drug formulations.

Conclusions:

  • BioMEMS technologies are advancing drug delivery through precise engineering at the micro-scale.
  • The integration of BioMEMS with computer controls and telemetry will further enhance their impact.
  • Continued development of BioMEMS promises significant improvements in personalized medicine and therapeutic efficacy.