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Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.

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Related Experiment Video

Updated: May 9, 2026

Engineering Cell-permeable Protein
21:08

Engineering Cell-permeable Protein

Published on: December 28, 2009

Engineering cell-cell signaling.

Katarina Blagovic1, Emily S Gong1, Daniel F Milano1

  • 1Department of Chemical Engineering, Northeastern University, Boston, MA.

Current Opinion in Biotechnology
|July 17, 2013
PubMed
Summary
This summary is machine-generated.

Engineering juxtacrine cell-cell signaling is challenging but crucial for biomedical applications. Advances in synthetic platforms and cells enable precise modulation of this signaling for tissue engineering and regenerative medicine.

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Silicon Microchips for Manipulating Cell-cell Interaction
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Silicon Microchips for Manipulating Cell-cell Interaction

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Related Experiment Videos

Last Updated: May 9, 2026

Engineering Cell-permeable Protein
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Engineering Cell-permeable Protein

Published on: December 28, 2009

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

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Silicon Microchips for Manipulating Cell-cell Interaction
23:21

Silicon Microchips for Manipulating Cell-cell Interaction

Published on: August 30, 2007

Area of Science:

  • Biomedical Engineering
  • Cellular Communication
  • Synthetic Biology

Background:

  • Juxtacrine cell-cell signaling, direct interaction between adjacent mammalian cells, presents significant engineering challenges.
  • Mastering juxtacrine signaling is vital for advancements in tissue engineering, regenerative medicine, immune system engineering, and therapeutic design.

Purpose of the Study:

  • To describe advances in synthetic platforms and synthetic cells for modulating juxtacrine cell-cell signaling.
  • To elucidate design rules and strategies for juxtacrine signaling based on quantitative engineering analysis.

Main Methods:

  • Development of synthetic platforms including materials and devices.
  • Engineering of synthetic cells via cell surface modification and synthetic gene circuits.
  • Quantitative analysis of mechanical and regulatory roles of juxtacrine signals within the microenvironment.

Main Results:

  • Significant progress in developing synthetic tools to modulate juxtacrine signaling.
  • Elucidation of design principles for engineering juxtacrine communication.
  • Demonstration of the feasibility of using quantitative analysis to understand signaling mechanics.

Conclusions:

  • Engineered juxtacrine signaling provides a foundation for integrative approaches in tissue engineering.
  • Synthetic cells, advanced chassis, and predictive modeling can be utilized to engineer tissue form and function.
  • Advances pave the way for creating complex living tissues with designed cellular communication.