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Updated: May 2, 2026

Ovarian Tissue Culture to Visualize Phenomena in Mouse Ovary
Published on: June 19, 2018
Follicle growth, ovulation, and luteal formation in primates and rodents: a comparative perspective
Charles L Chaffin1, Catherine A Vandevoort
1Department of OB/GYN & Reproductive Sciences, University of Maryland Baltimore, Baltimore, MD, USA. cchaffin@fpi.umaryland.edu
Abstract:
Ovarian function has a great deal of functional overlap between species; antral follicles grow in response to FSH, ovulation involves proteolysis, and the steroidogenic pathway is largely the same. However, embedded in these similarities are important differences that reflect the evolutionary and natural history of species and may focus future research into these critical areas. This review compares ovarian function of rats and mice with primates, focusing on estradiol and follicle growth, steroidogenesis and rupture during the periovulatory interval, and the formation of a functional corpus luteum, drawing the conclusion that careful comparison of species yields more functional information about both than studying them in isolation.
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