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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Updated: May 9, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
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Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

Published on: February 2, 2024

Recent progress in pancreatic cancer.

Christopher L Wolfgang1, Joseph M Herman, Daniel A Laheru

  • 1Associate Professor, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD; Associate Professor, Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD; Associate Professor, Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD.

CA: a Cancer Journal for Clinicians
|July 17, 2013
PubMed
Summary
This summary is machine-generated.

Pancreatic cancer treatment is advancing with safer surgery, improved drug combinations, and radiation therapy. Comprehensive, coordinated multidisciplinary care is essential for managing this complex disease effectively.

Keywords:
medical oncologymolecular biologypancreatic neoplasmsradiation oncologyradiology

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology
  • Radiation Oncology

Background:

  • Pancreatic cancer remains a leading cause of cancer-related mortality.
  • Despite challenges, significant progress has been made in treatment modalities.
  • Understanding the genetic landscape of pancreatic cancer has advanced considerably.

Purpose of the Study:

  • To highlight recent advancements in pancreatic cancer treatment.
  • To emphasize the growing complexity of patient care.
  • To advocate for a multidisciplinary approach in managing pancreatic cancer.

Main Methods:

  • Review of recent surgical techniques for pancreatic resection.
  • Analysis of novel drug combinations in clinical trials.
  • Evaluation of current radiation therapy protocols and their toxicity.
  • Exploration of fundamental genetic research in pancreatic cancer.

Main Results:

  • Surgical interventions for pancreatic neoplasms are increasingly safe and minimally invasive.
  • Novel therapeutic regimens demonstrate enhanced patient survival rates.
  • Radiation therapy exhibits reduced toxicity due to technological and methodological improvements.
  • Significant progress in understanding the underlying genetics of pancreatic cancer.

Conclusions:

  • Recent therapeutic advances offer renewed hope for patients with pancreatic cancer.
  • The complexity of managing pancreatic cancer necessitates specialized care.
  • Multidisciplinary care, offering comprehensive and coordinated evaluation and treatment, is the optimal strategy for patients.