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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
TMPRSS4 as a poor prognostic factor for triple-negative breast cancer
Daye Cheng1, Hong Kong, Yunhui Li
1Department of Transfusion, The First Hospital of China Medical University, Shenyang 110001, Liaoning, China. dayecheng_cmu@163.com
International Journal of Molecular Sciences
|July 17, 2013
Summary
Transmembrane protease, serine 4 (TMPRSS4) is highly expressed in triple-negative breast cancer (TNBC). High TMPRSS4 expression correlates with poorer survival outcomes and is an independent prognostic factor in TNBC patients.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Triple-negative breast cancer (TNBC) lacks estrogen receptors (ER), progesterone receptors (PR), and HER2 amplification.
- Identifying novel biomarkers for TNBC prognosis is crucial.
Purpose of the Study:
- To investigate the expression of transmembrane protease, serine 4 (TMPRSS4) in TNBC.
- To determine the relationship between TMPRSS4 expression and disease outcome in TNBC patients.
Main Methods:
- Compared TMPRSS4 expression in 72 TNBC and 109 non-TNBC patients using immunohistochemistry.
- Assessed prognostic significance via Kaplan-Meier analysis and Cox regression in TNBC patients.
Main Results:
- High TMPRSS4 expression was significantly more frequent in TNBC compared to non-TNBC.
- Elevated TMPRSS4 correlated with lymph node metastasis, higher histological grade, and larger tumor size.
- High TMPRSS4 expression was linked to poorer overall survival (OS) and disease-free survival (DFS).
- Lymph node metastasis and TMPRSS4 expression were independent prognostic factors for OS and DFS in TNBC.
Conclusions:
- TMPRSS4 expression is associated with adverse prognostic factors in TNBC, including metastasis, tumor size, and grade.
- TMPRSS4 serves as an independent prognostic biomarker for TNBC patients.
