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Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites
Armando Pérez-Rangel1, José Manuel Hernández, Araceli Castillo-Romero
1Departamento de Biología Celular, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, Col. San Pedro Zacatenco, 07360, México, DF Mexico.
Abstract:
In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.
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