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Updated: May 9, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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Responsive DNA-based hydrogels and their applications.

Xiangling Xiong1, Cuichen Wu, Cuisong Zhou

  • 1Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, Center for Research at Bio/Nano Interface, University of Florida, Gainesville, FL 32611-7200, USA.

Macromolecular Rapid Communications
|July 17, 2013
PubMed
Summary
This summary is machine-generated.

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DNA-based hydrogels are smart materials that change properties with stimuli. These versatile DNA hydrogels offer unique applications due to their biocompatibility and programmability.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Molecular Engineering

Background:

  • Hydrogels are cross-linked hydrophilic polymers known for water absorption.
  • Smart hydrogels exhibit property changes in response to external stimuli.
  • DNA's unique properties, including programmability and biocompatibility, make it ideal for advanced hydrogel design.

Purpose of the Study:

  • To review the stimulus response of DNA-based hydrogels.
  • To explore the diverse applications of DNA hydrogels.
  • To highlight the advantages of using DNA in hydrogel construction.

Main Methods:

  • Discussion of DNA hydrogel formation, including self-assembly and hybrid systems.
  • Analysis of stimulus-responsive mechanisms in DNA hydrogels.
Keywords:
DNAbiological applications of polymershydrogelsresponsive

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  • Overview of functional DNA components like aptamers and DNAzymes.

    • Main Results:

    • DNA hydrogels can be designed for specific responses to various environmental triggers.
    • Functional DNAs impart molecular recognition and enhanced versatility to hydrogels.
    • DNA-hybrid hydrogels combine synthetic polymer properties with DNA's programmability.

    Conclusions:

    • DNA-based hydrogels represent a promising class of smart materials.
    • Their tunable properties and biocompatibility open avenues for novel applications.
    • Further research into DNA hydrogels will drive innovation in responsive materials.