Related Experiment Video

Updated: May 9, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Soluble amyloid precursor protein 770 is a novel biomarker candidate for acute coronary syndrome

Shinobu Kitazume1, Akiomi Yoshihisa2, Takayoshi Yamaki2

  • 1Disease Glycomics Team, RIKEN-Max Planck Joint Research Center, Global Research Cluster, RIKEN, Wako, Saitama, Japan. shinobuk@riken.jp

Proteomics. Clinical Applications
|July 17, 2013
PubMed

Insights

Vascular endothelial cells produce amyloid precursor protein (APP) 770, which, when O-glycosylated, aids amyloid beta (Aβ) production. Elevated plasma sAPP770 may indicate endothelial dysfunction and serve as a biomarker for acute coronary syndrome.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Cardiology

Background:

  • Alzheimer disease is linked to amyloid beta (Aβ) deposition in the brain and vasculature.
  • Vascular endothelial cells express amyloid precursor protein (APP) 770, distinct from neuronal APP695.
  • Soluble APP (sAPP) is a potential Alzheimer disease diagnostic marker, but typically measured as a mixture.

Purpose of the Study:

  • To investigate the role of APP770 glycosylation and processing in Aβ production.
  • To explore the potential of sAPP770 as a specific biomarker for endothelial dysfunction.
  • To differentiate between endothelial and neurological contributions to disease by measuring APP variants separately.

Main Methods:

  • Analysis of APP770 glycosylation.
  • Investigating protease processing of O-glycosylated sAPP770.
  • Measuring plasma sAPP770 levels in patients with acute coronary syndrome.

Main Results:

  • O-glycosylated sAPP770 is preferentially processed for Aβ production.
  • Plasma sAPP770 levels are significantly elevated in patients with acute coronary syndrome.
  • sAPP770 shows potential as an indicator of endothelial dysfunction.

Conclusions:

  • sAPP770 is a distinct cleavage product of endothelial APP770.
  • sAPP770 may serve as a novel, specific biomarker for acute coronary syndrome.
  • Distinguishing between APP variants could improve diagnosis of endothelial versus neurological conditions.
Keywords:
Acute coronary syndromeAlzheimer diseaseAmyloid precursor proteinEndothelial cellGlycosylation

More Related Videos

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...