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Updated: May 9, 2026

Potentiodynamic Corrosion Testing
Published on: September 4, 2016
The effects on bone cells of metal ions released from orthopaedic implants. A review
Valerio Sansone1, Davide Pagani, Marco Melato
1Orthopaedic Department, University of Milan, "Istituto Ortopedico Galeazzi" IRCCS, Milano, Italy.
Abstract:
The increasing use of orthopedic implants and, in particular, of hip and knee joint replacements for young and active patients, has stimulated interest and concern regarding the chronic, long-term effects of the materials used. This review focuses on the current knowledge of the adverse biologic reactions to metal particles released from orthopaedic implants in vivo and in vitro. More specifically, the purpose of this article is to provide an overview of the current literature about the adverse effects of metal particles on bone cells and peri-implant bone.
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