Synthesis of 6-Se-guanosine RNAs for structural study
Jozef Salon1, Jianhua Gan, Rob Abdur
1Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.
Organic Letters
|July 18, 2013
Abstract:
6-Se-guanosine phosphoramidite and RNAs have been synthesized by selenium substitution of the 6-oxygen atom, and it is revealed that the Se-derivatization is relatively stable and that bulge and wobble structures can better accommodate a large Se atom than a duplex. This Se-modification is useful in the structural study of RNAs and their protein complexes.
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