[Clinical analyses of perinuclear antineutrophil cytoplasmic antibody associated hypertrophic pachymeningitis]
Related Experiment Video
Updated: May 9, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
1Department of Neurology, General Hospital, Tianjin Medical University, Tianjin 300052, China. zhaopeng7824@126.com
Objective:
To explore the clinical characteristics, diagnosis, treatment and prognosis of perinuclear antineutrophil cytoplasmic antibody (p-ANCA) associated hypertrophic pachymeningitis.
Methods:
A retrospective study was performed for 6 inpatients with p-ANCA associated hypertrophic pachymeningitis at our hospital from 2005 to 2012.
Results:
There were 3 males and 3 females with an age range of 52 - 68 years. The main clinical manifestations included headache and multiple cranial neuropathies. Erythrocyte sedimentation rate, C-reactive protein, titer of myeloperoxidase (MPO)-ANCA and protein in cerebrospinal fluid were uniformly elevated in all 6 patients during active phase while cytoplasmic(c)-ANCA was all negative. Head magnetic resonance imaging (MRI) enhancement scan had a high diagnostic sensitivity. Different parts of dura were all thickened and obviously enhanced. Glucocorticoid was uniformly effective. During the follow-up period, 2 cases relapsed and received immunosuppressive agents.
Conclusion:
The disease should be considered in elderly patients with headache, cranial nerve injury and positive p-ANCA. And head MRI enhancement scan is helpful for diagnosis.
Related Concept Videos
Viral Meningitis
Bacterial Meningitis I: Introduction
Acute Pyelonephritis II: Diagnostic Studies and Management
Bacterial Meningitis II: Pathophysiology
Pericarditis II: Clinical Features and Diagnostic Tests
