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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Equine glaucoma: a histopathologic retrospective study (1999-2012).

Elizabeth M Curto1, Anne J Gemensky-Metzler, Heather L Chandler

  • 1College of Optometry, The Ohio State University, Columbus, OH, 43210, USA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, 43210, USA.

Veterinary Ophthalmology
|July 18, 2013
PubMed
Summary

Equine glaucoma, often secondary to uveitis, commonly affects older horses and specific breeds like Appaloosas. Histopathologic findings reveal optic nerve hypercellularity and retinal atrophy in affected eyes.

Keywords:
equineglaucomahistopathologyintraocular hypertensionuveitis

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Area of Science:

  • Veterinary Ophthalmology
  • Equine Pathology

Background:

  • Glaucoma is a significant cause of vision loss in horses.
  • Understanding the histopathologic basis of equine glaucoma is crucial for diagnosis and management.

Purpose of the Study:

  • To characterize and describe the histopathologic findings in equine globes enucleated due to glaucoma.
  • To identify common lesions and potential predisposing factors in equine glaucoma cases.

Main Methods:

  • Retrospective review of medical records from The Ohio State University (1999-2012).
  • Histologic examination of 23 enucleated equine globes.
  • Recording of signalment, history, treatment data, and specific histopathologic lesions.

Main Results:

  • Most affected horses were older than 15 years (65%), with Quarter Horses, Appaloosas, and Thoroughbreds being common breeds.
  • Frequent histopathologic changes included optic nerve hypercellularity (93%), retinal atrophy (89%), and corneal vascularization (83%).
  • Uveitis was present in 87% of eyes, often associated with posterior bowing of the iris base and ciliary body atrophy.

Conclusions:

  • Equine glaucoma is frequently secondary to uveitis, with Appaloosas and older horses showing predisposition.
  • Histologic changes are similar to chronic glaucoma in other species.
  • Posterior bowing of the iris base and relative sparing of the superior retina were notable findings.