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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Bioadhesive polymers: novel tool for drug delivery
Krishan Kumar1, Neha Dhawan, Harshita Sharma
1Nanomedicine Research Centre, Department of Pharmaceutics, ISF College of Pharmacy , Moga, Punjab 142001 , India.
Artificial Cells, Nanomedicine, and Biotechnology
|July 18, 2013
Summary
Mucoadhesive drug delivery systems utilize interfacial forces for prolonged drug contact. These systems enhance therapeutic effects and systemic drug availability by increasing residence time at the application site.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Science
- Drug Delivery
Background:
- Mucoadhesive drug delivery systems emerged in the early 1980s as a widely researched novel delivery approach.
- Mucoadhesion involves the adhesion of a drug carrier to biological mucus through interfacial forces, ensuring prolonged contact.
- Numerous polymers exhibiting bioadhesive properties are integral to formulating both conventional and advanced drug delivery systems.
Purpose of the Study:
- To elucidate the fundamental principles of mucoadhesion.
- To explore the mechanisms underlying bioadhesion.
- To review polymers utilized in bioadhesive delivery systems and their influence on mucoadhesion.
Main Methods:
- Literature review focusing on mucoadhesion research.
- Analysis of interfacial phenomena between mucoadhesives and mucus.
- Examination of polymer properties relevant to bioadhesion.
Main Results:
- Mucoadhesion enhances local therapeutic activity and systemic drug availability.
- Increased residence time at the application site is a key benefit of mucoadhesive systems.
- Understanding polymer properties is crucial for designing effective bioadhesive systems.
Conclusions:
- Mucoadhesive systems offer significant advantages in drug delivery by prolonging drug action.
- The selection of appropriate polymers with specific properties is critical for successful mucoadhesive formulation.
- Further research into mucoadhesion mechanisms and polymer interactions will advance drug delivery technologies.
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