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Updated: May 9, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Focal cortical dysplasia.

John N Gaitanis¹, John Donahue

¹Department of Neurology and Pediatrics (Clinical), The Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA. John_Gaitanis@Brown.edu

Pediatric Neurology

|July 18, 2013

Summary

Focal cortical dysplasias (FCDs) are a leading cause of pediatric epilepsy. While diagnosis is improving with neuroimaging, effective treatments remain limited, though epilepsy surgery offers hope for some.

Area of Science:

Neurology
Pediatric Epilepsy
Neurodevelopmental Disorders

Background:

Focal cortical dysplasias (FCDs) are a primary cause of drug-resistant epilepsy in children.
Understanding FCD neuropathology has led to evolving diagnostic criteria and nomenclature.
Advances in neuroimaging enhance the detection and characterization of FCDs.

Purpose of the Study:

To review the current understanding of focal cortical dysplasias in pediatric epilepsy.
To highlight the diagnostic challenges and advancements in neuroimaging for FCDs.
To discuss current and future therapeutic strategies for FCD-associated epilepsy.

Main Methods:

Review of neuropathological findings in focal cortical dysplasias.
Analysis of clinical, electroencephalographic, and neuroimaging data for diagnosis.

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Evaluation of treatment outcomes, including medical and surgical interventions.

Main Results:

FCDs are a significant cause of intractable childhood epilepsy.
Neuroimaging, particularly advanced techniques, is crucial for FCD detection.
Current treatments are often symptomatic; epilepsy surgery can be effective in select cases.

Conclusions:

Accurate recognition of FCD patterns is essential for diagnosis and management.
Novel therapeutic approaches may emerge from ongoing basic science research.
Epilepsy surgery remains a viable option for selected pediatric patients with FCDs.