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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
Published on: January 27, 2022
Experimental evidence and early translational steps using bone marrow derived stem cells after human stroke
Yukiko Kasahara1, Masafumi Ihara, Akihiko Taguchi
1Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan.
Frontiers of Neurology and Neuroscience
|July 18, 2013
Summary
Neurogenesis, the creation of new neurons, occurs in specific brain regions. Therapeutic angiogenesis supports stem cells in stroke recovery, enhancing neuroregeneration and functional recovery.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Neurology
Background:
- Neurogenesis is primarily confined to the subventricular and subgranular zones under normal physiological conditions.
- Following stroke, neural stem cells migrate to the injured brain areas, indicating potential for endogenous repair.
- Mobilization of neural stem cells is observed in both animal models and human patients post-stroke.
Purpose of the Study:
- To review experimental and clinical findings on neurogenesis in the injured brain after cerebral infarction.
- To explore the potential of cell-based therapies, specifically using autologous bone marrow-derived stem/progenitor cells, for stroke recovery.
- To discuss challenges in neuroregeneration, including the context of the aging brain.
Main Methods:
- Review of recent experimental studies investigating neurogenesis post-stroke.
- Analysis of clinical data from cell-based therapy trials in stroke patients.
- Examination of therapeutic angiogenesis strategies to support endogenous stem cells.
Main Results:
- Therapeutic angiogenesis enhances neuroregeneration and functional recovery in experimental stroke models by supporting mobilized stem cells.
- Neural stem cells are demonstrably mobilized to peri-infarct areas in both animal models and human stroke patients.
- Cell-based therapy using autologous bone marrow-derived stem/progenitor cells is being explored clinically.
Conclusions:
- Neurogenesis and stem cell mobilization offer promising avenues for brain repair after stroke.
- Cell-based therapies, supported by strategies like therapeutic angiogenesis, hold potential for improving functional outcomes in stroke patients.
- Addressing challenges in neuroregeneration, particularly in aged individuals, is crucial for advancing future therapies.
