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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

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Related Experiment Video

Updated: May 9, 2026

Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies
08:41

Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies

Published on: December 15, 2014

Rehabilitation and plasticity.

Andreas R Luft1

  • 1Department of Neurology, University Hospital of Zurich, Frauenklinikstrasse 26, Zürich, Switzerland. andreas.luft@uzh.ch

Frontiers of Neurology and Neuroscience
|July 18, 2013
PubMed
Summary
This summary is machine-generated.

Neurorehabilitation therapies leverage neuroplasticity, the brain's ability to reorganize. Optimizing complex, multifactorial interventions requires developing treatment protocols before large clinical trials.

More Related Videos

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Related Experiment Videos

Last Updated: May 9, 2026

Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies
08:41

Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies

Published on: December 15, 2014

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine

Background:

  • Neurorehabilitation aims to restore lost function after injury by utilizing the brain's capacity for change, known as neuroplasticity.
  • Current therapeutic approaches focus on neural circuit reorganization within intact brain tissue.

Purpose of the Study:

  • To outline the key components and considerations for developing effective neuroplasticity-based rehabilitation strategies.
  • To highlight the complexity of these interventions and the need for optimized protocols.

Main Methods:

  • Review of neuroplasticity principles and their application in rehabilitation.
  • Identification of essential therapeutic elements: intensive training, motivation, interactive devices, and supportive therapies (e.g., brain stimulation, medications).

Main Results:

  • Neuroplasticity-based therapies involve intensive, repetitive training and patient motivation.
  • Interactive devices and supportive therapies like brain stimulation or medications can enhance neuroplasticity.

Conclusions:

  • Effective neurorehabilitation relies on harnessing neuroplasticity through a combination of intensive training and supportive interventions.
  • The complexity of these multifactorial interventions necessitates the development of optimized treatment protocols to ensure efficacy in large-scale clinical trials.