Related Experiment Video
Updated: May 9, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Revised Cardiac Risk Index (RCRI) is a useful tool for evaluation of perioperative cardiac morbidity in kidney
Nir Hoftman1, Adrian Prunean, Anahat Dhillon
11 Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA. 2 Transplant Nephrology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA. 3 Cardiology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA. 4 Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA. 5 Address correspondence to: Hans Albin Gritsch, M.D., 10945 Le Conte Avenue, PVUB 3361, Los Angeles, CA 90095-7309.
Insights
The Revised Cardiac Risk Index (RCRI) effectively predicts cardiovascular complications in kidney transplant patients. This tool can guide care protocols to minimize risks during and after transplantation.
Area of Science:
- Nephrology
- Cardiology
- Transplant Surgery
Background:
- Assessing preoperative cardiovascular risk is crucial for kidney transplant recipients.
- The Revised Cardiac Risk Index (RCRI) is a validated tool for cardiac risk stratification.
- Its utility in the unique kidney transplant population requires evaluation.
Purpose of the Study:
- To evaluate the effectiveness of the Revised Cardiac Risk Index (RCRI) in predicting cardiovascular complications in kidney transplant recipients.
- To determine if RCRI can be utilized as a preoperative cardiovascular risk stratification tool in this patient group.
Main Methods:
- Retrospective chart review of 1652 kidney transplant recipients (2005-2009).
- Analysis included 169 recipients with preoperative coronary angiography and 156 age/transplant year-matched controls without angiography.
- Preoperative cardiovascular risk factors and perioperative cardiac complications were assessed.
Main Results:
- The number of RCRI risk factors strongly predicted cardiovascular complications (ROC area=0.77, P<0.0001).
- History of coronary artery disease showed a significant association (OR=20.59, P=0.0001).
- History of congestive heart failure was also significantly associated (OR=2.95, P=0.0475).
Conclusions:
- The Revised Cardiac Risk Index (RCRI) is a valuable tool for cardiac risk stratification in kidney transplant recipients.
- RCRI can inform the development of targeted intraoperative and postoperative care protocols.
- Utilizing RCRI may help minimize cardiovascular complications in this population.
Background:
We evaluated a published Revised Cardiac Risk Index (RCRI) to determine if this preoperative cardiovascular risk stratification tool would be useful in the kidney transplant recipient population.
Methods:
We identified all kidney transplants from 2005 to 2009 (n=1652) at our institution. We performed a detailed retrospective chart review of (a) all recipients who underwent preoperative coronary angiography (n=169) and (b) an age-matched and transplantation year-matched group who did not undergo coronary angiography (n=156). Charts were reviewed for the presence of specific preoperative cardiovascular risk factors and perioperative cardiovascular complications (as defined by RCRI plus elevation of troponin) from time of surgery to hospital discharge. The total number of risk factors for each patient was compared with the occurrence of postoperative cardiac complications to identify a possible association.
Results:
The number of risk factors was highly predictive of cardiovascular complications (receiver operating characteristic area, 0.77; P<0.0001). History of coronary artery disease was most strongly associated (odds ratio, 20.59; confidence interval, 4.73-89.53; P=0.0001) and history of congestive heart failure was also significantly associated with cardiac complications (odds ratio, 2.95; confidence interval, 1.01-8.59; P=0.0475).
Conclusion:
The RCRI is a useful tool for cardiac risk stratification in kidney transplantation and could be used to develop protocols for intraoperative and postoperative care to minimize complications.
Related Concept Videos
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Acute Kidney Injury I: Introduction
Kidney Transplant I: Introduction
Kidney Transplant II: Surgical Procedure
Continuous Renal Replacement Therapy
Cardiac Catheterization I: Pre-Procedure Overview