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Related Experiment Videos

Phospholipase C-sensitive factor VIII activity in normal pregnancy.

K Dalaker1, O C Ingebretsen, S Rasmussen

  • 1Department of Obstetrics and Gynecology, University of Tromsø, Norway.

Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1990
PubMed
Summary

A phospholipase C-sensitive factor VII complex in pregnancy strongly correlates with serum triglycerides and platelet count. Further research is needed to understand the formation of this factor VII-phospholipid complex.

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Area of Science:

  • Biochemistry
  • Hematology
  • Obstetrics

Background:

  • A phospholipase C-sensitive form of factor VII, likely a factor VII-phospholipid complex, has been identified in normal pregnancy.
  • The formation mechanism of this complex remains unclear.

Purpose of the Study:

  • To investigate the correlations between the levels of the factor VII-phospholipid complex and other physiological markers during pregnancy.

Main Methods:

  • Bivariate regression analysis was employed to assess relationships.
  • Stepwise multiple regression analysis was used for verification.

Main Results:

  • The factor VII complex level showed a highly significant positive correlation with serum triglycerides (r = 0.90, p < 0.0001).

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  • A significant positive correlation was also observed with blood platelet count (r = 0.067, p = 0.0004).

    • Conclusions:

    • The factor VII-phospholipid complex in pregnancy is strongly associated with elevated serum triglycerides and increased platelet counts.
    • The precise pathway for the formation of this complex requires further elucidation.