Related Experiment Video
Updated: May 5, 2026
07:48
A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
Published on: December 18, 2015
19.3K
Unravelling stem cell dynamics by lineage tracing.
Cédric Blanpain1, Benjamin D Simons
1Université Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Brussels, Belgium. Cedric.Blanpain@ulb.ac.be
Nature Reviews. Molecular Cell Biology
|July 18, 2013
Summary
Stem and progenitor cell fate is crucial for tissue development and homeostasis. New lineage-tracing and statistical methods reveal cell dynamics in development, repair, and disease.
Area of Science:
- Developmental biology
- Stem cell biology
- Tissue homeostasis
Background:
- Cellular development and tissue renewal are precisely regulated processes.
- Stem and progenitor cells are key to development, homeostasis, and repair.
- Dysregulation of cell fate contributes to tumor formation.
Purpose of the Study:
- To explore mechanisms of stem and progenitor cell fate determination.
- To investigate cell dynamics during development, tissue maintenance, and repair.
- To understand how cell fate dysregulation contributes to tumor formation.
Main Methods:
- Utilizing lineage-tracing and genetic labeling technologies.
- Employing statistical approaches, including proliferation assays and clonal fate analyses.
- Applying these techniques in transgenic mouse models and other systems.
Main Results:
- Shedding light on the mechanisms and dynamics of cell fate determination.
- Providing quantitative insights into cell kinetics and fate behavior.
- Enabling the study of cell fate dysregulation in tumor formation.
Conclusions:
- Lineage-tracing and statistical methods are powerful tools for studying cell fate.
- These techniques address fundamental questions in developmental and stem cell biology.
- Understanding cell kinetics is vital for tissue repair and disease research.
More Related Videos
Related Concept Videos
01:56Gastrulation
52.8K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
52.8K
01:21Lineage Commitment
3.4K
Commitment is the process whereby stem cells:
3.4K
01:10Zygotic Development And Stem Cell Formation
6.4K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
6.4K
01:26Stem Cell Niche
5.0K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.0K
01:06Multipotency and Niche of Bulge Stem Cell
2.9K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
2.9K