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[Recommendations for the treatment of heart failure : What's new?]
G Hasenfuß1, F Edelmann, R Wachter
1Klinik für Kardiologie und Pneumologie, Herzzentrum, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland. hasenfus@med.uni-goettingen.de
Insights
Treatment escalation for chronic systolic heart failure in symptomatic patients with reduced ejection fraction (≤30%) involves ACE inhibitors, beta-blockers, and other therapies. Device-based treatments like ICDs and CRT are also key considerations.
Area of Science:
- Cardiology
- Internal Medicine
Context:
- Chronic systolic heart failure management requires tailored treatment escalation based on patient status.
- Severely reduced left ventricular function (ejection fraction ≤30%) necessitates a multi-faceted therapeutic approach.
Purpose:
- To outline recommended treatment escalation strategies for symptomatic patients with severely reduced left ventricular function.
- To provide a comprehensive overview of pharmacological and device-based interventions.
Summary:
- Recommended therapies include ACE inhibitors (or ARBs), beta-blockers, mineralocorticoid receptor antagonists, and diuretics for congestion.
- Further options include digitalis, ivabradine, implantable cardioverter defibrillators (ICDs), and cardiac resynchronization therapy (CRT).
- Intravenous iron for deficiency and exercise training for stable patients are also advised.
Impact:
- Optimizing treatment strategies can improve outcomes for patients with advanced systolic heart failure.
- This guideline aids clinicians in selecting appropriate interventions for complex heart failure cases.
- Highlights the importance of a personalized and comprehensive approach to heart failure management.
Abstract:
Treatment escalation of chronic systolic heart failure depends on left ventricular function and symptoms of the patients. In symptomatic patients with severely reduced left ventricular function (ejection fraction ≤ 30 %), the following therapeutic approaches are recommended: (1) angiotensin-converting enzyme (ACE) inhibitors (angiotensin receptor blocker in case of ACE inhibitor intolerance); (2) β-blockers; (3) mineralocorticoid receptor antagonists; (4) diuretics in case of signs and symptoms of congestion; (5) digitalis, in particular in patients with atrial fibrillation; (6) ivabradine in patients with sinus rhythm and a heart rate ≥ 75/min; (7) an implantable cardioverter defibrillator (ICD); (8) in case of left bundle branch block or wide QRS complex, cardiac resynchronization therapy (CRT; in most cases in combination with an implantable cardioverter defibrillator); (9) intravenous administration of iron in case of iron deficiency; (10) exercise training should be strongly recommended in patients with stable heart failure.
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