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Inversion-mediated gene fusions involving NAB2-STAT6 in an unusual malignant meningioma
1Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Background:
Meningiomas are the most common primary intracranial tumours, with ∼3% meeting current histopathologic criteria for malignancy.
Methods:
In this study, we explored the transcriptome of meningiomas using RNA-Seq.
Results:
Inversion-mediated fusions between two adjacent genes, NAB2 and STAT6, were detected in one malignant tumour, creating two novel in-frame transcripts that were validated by RT-PCR and Sanger sequencing.
Conclusion:
Gene fusions of NAB2-STAT6 were recently implicated in the pathogenesis of solitary fibrous tumours; our study suggested that similar fusions may also have a role in a malignant meningioma with unusual histopathologic features.
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