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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: May 9, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

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Published on: September 16, 2017

QTc-prolongation in posterior circulation stroke.

Nils Henninger¹, Diogo C Haussen, Nikolaos Kakouros

¹Department of Neurology, UMass Medical School, 55 Lake Ave, North, Worcester, MA, 01655, USA, nils.henninger@umassmed.edu.

Neurocritical Care

|July 18, 2013

Summary

This summary is machine-generated.

QTc-prolongation is common in posterior circulation stroke patients and linked to temporal lobe infarcts. This association highlights potential risks and areas for further research in stroke outcomes.

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Area of Science:

Cardiology
Neurology
Clinical Electrophysiology

Background:

Posterior circulation strokes can lead to cardiac complications.
QTc interval prolongation is a known risk factor for adverse cardiac events.

Purpose of the Study:

To investigate the association between infarct location in posterior circulation strokes and QTc prolongation.
To identify predictors of QTc prolongation in this patient population.

Main Methods:

Retrospective analysis of electrocardiograms (ECGs) from 131 patients with posterior circulation strokes.
QTc interval measured and corrected using Bazett's formula (QTcBazett) and linear regression (QTcLinear).
Multivariable regression analyses to determine independent predictors of QTc prolongation.

Main Results:

34% of patients exhibited prolonged QTcBazett, and 7% had prolonged QTcLinear.
Temporal lobe infarction was significantly associated with both QTcBazett and QTcLinear.
Temporal lobe infarction independently predicted QTc prolongation in logistic regression models.

Conclusions:

QTc prolongation is frequent following posterior circulation stroke.
Temporal lobe infarction is a key factor associated with QTc prolongation in these patients.
Further prospective studies are warranted to confirm findings and explore long-term implications.