Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

Vitamins

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...

Muscle Recovery and Fatigue

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-dose thiamine and essential tremor.

BMJ case reports·2018

Same author

Can long-term thiamine treatment improve the clinical outcomes of myotonic dystrophy type 1?

Neural regeneration research·2016

Same author

Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia.

Journal of neurology·2016

Same author

Thiamine and dystonia 16.

BMJ case reports·2016

Same author

An open-label pilot study with high-dose thiamine in Parkinson's disease.

Neural regeneration research·2016

Same author

Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study.

Journal of alternative and complementary medicine (New York, N.Y.)·2015

Search research articles

Related Experiment Video

Updated: May 9, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

High dose thiamine improves fatigue in multiple sclerosis.

Antonio Costantini¹, Agostino Nappo, Maria Immacolata Pala

¹Department of Neurological Rehabilitation, Villa Immacolata, Viterbo, Italy. carapetata@libero.it

BMJ Case Reports

|July 18, 2013

Summary

High-dose thiamine therapy significantly improved fatigue in multiple sclerosis (MS) patients, even with normal blood thiamine levels. This suggests intracellular thiamine transport or enzyme issues may cause MS fatigue.

More Related Videos

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Related Experiment Videos

Last Updated: May 9, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Area of Science:

Neurology
Nutritional Neuroscience
Biochemistry

Background:

Multiple sclerosis (MS) frequently causes debilitating fatigue.
Fatigue in MS may be linked to intracellular thiamine deficiency.
Thiamine (vitamin B1) is crucial for energy metabolism and neurological function.

Observation:

Fifteen MS patients with fatigue were studied.
Standard blood tests showed normal thiamine and thiamine pyrophosphate levels.
The Fatigue Severity Scale assessed fatigue severity.

Findings:

High-dose oral or parenteral thiamine therapy led to significant fatigue improvement in MS patients.
Despite normal blood levels, symptoms suggested intracellular thiamine deficiency.
This implies potential issues with intracellular thiamine transport or enzymatic function.

Implications:

High-dose thiamine may be a viable therapeutic strategy for MS-related fatigue.
Overcoming intracellular thiamine deficits via supranormal concentrations is feasible.
Further research into thiamine metabolism in MS is warranted.